The integrin-actin connection
Horton, E.R., Byron, A., Askari, J.A., Ng, D.H.J., Millon-Frémillon, A., Robertson, J., Koper, E.J., Paul, N.R., Warwood, S., Knight, D., Humphries, J.D. and Humphries, M.J.(2015). Definition of a consensus integrin adhesome and analysis of its dynamics during adhesion complex assembly and disassembly. Nature Cell Biol. 17, 1577-87.
Integration of seven mass spectrometric analysis of the adhesion nexus demonstrated that a small number of proteins (tens) establish its framework and a larger cohort of more transient proteins (hundreds) tune its function to intra- and extracellular stimuli. Analysis of the protein-protein interaction network of the adhesion nexus identified four interconnected axes that relay force to the cytoskeleton.