Anti-integrin antibodies

Anti-integrin antibodies

Changes in integrin shape regulate its activation state. Monoclonal antibodies that detect conformation-dependent integrin epitopes have been produced. These antibodies enable the study of dynamic conformational changes of integrin.

Anti-integrin antibodies, by Adam Byron

Further reading

  • A Byron, JD Humphries, JA Askari, SE Craig, AP Mould and MJ Humphries (2009) Anti-integrin monoclonal antibodies. J. Cell Sci. 122: 4009-11.
    Full text | PubMed entry
  • JD Humphries, NR Schofield, Z Mostafavi-Pour, LJ Green, AN Garratt, AP Mould and MJ Humphries (2005) Dual functionality of the anti-β1 integrin antibody, 12G10, exemplifies agonistic signalling from the ligand binding pocket of integrin adhesion receptors. J. Biol. Chem. 280: 10234-43. Full text | PubMed entry
  • AP Mould, MA Travis, SJ Barton, JA Hamilton, JA Askari, SE Craig, PR Macdonald, RA Kammerer, PA Buckley and MJ Humphries (2005) Evidence that monoclonal antibodies directed against the integrin β subunit plexin/semaphorin/integrin domain stimulate function by inducing receptor extension. J. Biol. Chem. 280: 4238-46. Full text | PubMed entry

Anti-integrin antibodies – right hand column

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