Integrin ligands

Integrin extracellular domains bind to either ECM macromolecules or counter-receptors on adjacent cell surfaces. Most integrin receptors can bind a wide variety of ligands. Moreover, many ECM and cell adhesion proteins can bind to multiple integrin receptors.

Further reading

JD Humphries*, A Byron* and MJ Humphries (2006) Integrin ligands at a glance. J. Cell Sci. 119: 3901-3. Full text | PubMed entry

AP Mould, JA Askari and MJ Humphries (2000) Molecular basis of ligand recognition by integrin α5β1. I. Specificity of ligand binding is determined by amino acid sequences in the second and third NH2-terminal repeats of the α subunit. J. Biol. Chem. 275: 20324-20336. Full text | PubMed entry

AP Mould, LA Wheldon, A Komoriya, EA Wayner, KM Yamada and MJ Humphries (1990) Affinity chromatographic isolation of the melanoma adhesion receptor for the IIICS region of fibronectin and its identification as the integrin α4β1. J. Biol. Chem. 265: 4020-4024. Full text | PubMed entry

* These authors contributed equally to this work.